Dataset for 'A multivalent capsule vaccine protects against Klebsiella pneumoniae bloodstream infections in healthy and immunocompromised mice'
Description
In the accompanying publication, we reported on the production and characterization of the broadest K. pneumoniae capsule bioconjugate vaccine to date. We tested this vaccine for its immunogenicity, functionality, efficacy, and antibody durability against a variety of K. pneumoniae isolates in a murine bacteremia model. We also established an immunocompromised murine model of bacteremia to better recapitulate human infection and tested our vaccine’s efficacy in this background. The data included in the metadata set includes ELISAs, serum bactericidal assay, opsonophagocytosis assay, and survival curves. All data was generated in mice. GraphPad Prism is needed to open the data files. To view the data, use the free viewer mode of the software.
Files
Steps to reproduce
All data was generated as described in the methods of the manuscript. All data was generated using GraphPad Prism.
Institutions
- Washington University in St. Louis
- National Research Council Canada
- The University of Melbourne
Categories
Funders
Additional Metadata for Digital Commons Data@Becker
| Keywords | Klebsiella pneumoniae, Vaccine, Capsular polysaccharide, Bioconjugation, Bloodstream infections, Immunocompromised mouse model |
| Other Contributing Institutions | Ominose |