Dataset for 'Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves'
Published: 25 June 2026| Version 1 | DOI: 10.17632/mv3crjbcsg.1
Contributors:
, , , , , , , Description
This dataset contains quantitative summary data supporting the publication "Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves". The data include LC-MS/MS metabolomics measurements, in vitro axon degeneration assays, and in vivo histological and behavioral analyses used to generate the quantitative results presented in Figures 1–4 and Supplemental Figure S1. These data support the study's investigation of chronic SARM1 activation, phosphatidylserine dysregulation, macrophage activation, and the therapeutic effects of neuronal ABHD12 overexpression in a mouse model of sarmopathy.
Files
Steps to reproduce
Complete STAR★Methods available at https://doi.org/10.1016/j.isci.2025.112626
Institutions
- Washington University in St. LouisMissouri, St Louis
Categories
Immunology, Molecular Neuroscience
Funders
- National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaGrant ID: 5R01NS087632
- National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaGrant ID: 5R01NS133348
- National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaGrant ID: R01NS119812
- National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaGrant ID: R01AG013730
Additional Metadata for Digital Commons Data@Becker
| Keywords | SARM1, NMNAT2, ABDH12, Phosphatidylserines, Neurodegenerative Diseases, Degeneration |