Supplemental data: The sphingosine-1-phosphate pathway is differentially activated in human gestational tissues
Description
Using qPCR and targeted LC–MS/MS, we profiled S1P metabolic enzymes, receptors, and metabolites in human gestational tissues across pregnancy. These findings reveal tissue-specific regulation of S1P metabolism and signaling in human gestational tissues, suggesting a therapeutic role of S1P in modulating myometrial contractility. The collection of this data was conducted with the approval of the Washington University in St. Louis Institutional Review Board (ID# 202205099).
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Myometrium, decidua parietalis, and chorioamnion were collected from women undergoing cesarean sections at term (≥37 weeks’ gestation) without labor (TNL, n=8), term with labor (TL, n=5), and preterm (<37 weeks’ gestation) without labor (PTNL, n=6). Messenger RNA (mRNA) expression of S1P metabolic enzymes and receptors was assessed using quantitative polymerase chain reaction, while sphingolipids were quantified using targeted liquid chromatography-tandem mass spectrometry. Full methodology is outlined in the manuscript.
Institutions
- Washington University in St. LouisMO, Saint Louis
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Funders
- National Center for Advancing Translational SciencesNational Institutes of HealthUnited StatesGrant ID: UL1TR002345
Additional Metadata for Digital Commons Data@Becker
| Keywords | decidua parietalis, metabolomics, myometrium, S1P, sphingolipids, labor, pregnancy |