Dataset for "A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice"
Published: 16 March 2026| Version 2 | DOI: 10.17632/pb3zw99wfs.2
Contributors:
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This dataset contains the raw data supporting all main and supplementary figures used in the manuscript "A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice" published in Cell Host & Microbe. The data contains viral and antibody titers and T cell responses in mice not-vaccinated, intramuscularly and/or mucosally vaccinated, and then infected with SARS-CoV-1, SARS-CoV-2, or other pre-emergent bat coronaviruses.
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Steps to reproduce
Refer to the STAR METHODS section of the manuscript
Institutions
- La Jolla Institute for ImmunologyCalifornia, San Diego
- Washington University in St. LouisMO, Saint Louis
- Harvard UniversityMA, Cambridge
- University of Maryland, BaltimoreMaryland, Baltimore
- J. Craig Venter InstituteCalifornia, La Jolla
- Ragon Institute of MGH, MIT and HarvardMassachusetts, Cambridge
Categories
Immunology, Virology, Infectious Disease, Microbial Pathogenesis
Funders
- United States National Library of MedicineUnited States
Additional Metadata for Digital Commons Data@Becker
| Keywords | SARS-CoV-2, Mouse Model, Ancestral Phylogenetic Reconstructions, Trivalent Pan-Sarbecovirus Vaccine |
| Revision History | v2: Update ROR ID. Update ORCID. |