Dataset for 'LRP8 is an entry receptor for tick-borne encephalitis viruses'
Published: 1 October 2025| Version 1 | DOI: 10.17632/x4483f3rmk.1
Contributors:
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This dataset contains the raw data supporting all main and supplementary figures used in the manuscript "LRP8 is an entry receptor for tick-borne encephalitis viruses" published in PNAS. In this study, we expressed 13 different family members on the surface of cells and demonstrated that LRP8 promotes infection of tick-borne encephalitis viruses (TBEV). Validation studies confirmed direct binding of TBEV and LRP8, and a key role for LRP8 in neuronal cell infection. Our findings also enabled the generation of an inhibitory LRP8-Fc decoy molecule that blocks TBEV infection.
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Steps to reproduce
Refer to the METHODS section of the manuscript
Institutions
- Washington University in St. Louis
- University of Texas Medical Branch at Galveston
Categories
Microbiology, Virology
Funders
Additional Metadata for Digital Commons Data@Becker
| Keywords | orthoflavivirus, tropism, receptor, cell entry |