Dataset for 'LRP8 is an entry receptor for tick-borne encephalitis viruses'
Published: 1 October 2025| Version 1 | DOI: 10.17632/x4483f3rmk.1
Contributors:
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This dataset contains the raw data supporting all main and supplementary figures used in the manuscript "LRP8 is an entry receptor for tick-borne encephalitis viruses" published in PNAS. In this study, we expressed 13 different family members on the surface of cells and demonstrated that LRP8 promotes infection of tick-borne encephalitis viruses (TBEV). Validation studies confirmed direct binding of TBEV and LRP8, and a key role for LRP8 in neuronal cell infection. Our findings also enabled the generation of an inhibitory LRP8-Fc decoy molecule that blocks TBEV infection.
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Steps to reproduce
Refer to the METHODS section of the manuscript
Institutions
Washington University in St. Louis, University of Texas Medical Branch at Galveston
Categories
Microbiology, Virology
Funders
Additional Metadata for Digital Commons Data@Becker
| Keywords | orthoflavivirus, tropism, receptor, cell entry |