Intranasal and intramuscular H5-Matrix-M nanoparticle vaccines protects against highly pathogenic Influenza A (H5N1) virus in mice [dataset]

Name: Intranasal and intramuscular H5-Matrix-M nanoparticle vaccines protects against highly pathogenic Influenza A (H5N1) virus in mice [dataset]
Creator: Kelly Pyles
Published: 2026-07-06T18:06:51.663Z
Keywords: Immunology, Vaccine

Pyles, Kelly; Darling, Tamarand; Huang, Lin-Chen; Guebre-Xabier, Mimi; Hersey, Melinda; Greene, Annie; Patel, Nita; Smith, Gale; Boon, Adrianus CM

doi:10.17632/x8b2f87c99.1

Intranasal and intramuscular H5-Matrix-M nanoparticle vaccines protects against highly pathogenic Influenza A (H5N1) virus in mice [dataset]

Published: 6 July 2026| Version 1 | DOI: 10.17632/x8b2f87c99.1

Contributors:

,

Description

In this work, we characterized the immunogenicity and efficacy of a Matrix-M®–adjuvanted nanoparticle protein vaccine containing recombinant H5 HA of A/American wigeon/South Carolina/22/000345-001/2021 virus (clade 2.3.4.4b, H5-MNP). Influenza A virus (H5N1) animal challenge model involves BL/6 mice and Madin-Darby Canine Kidney epithelial (MDCK) cells. Data types include Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) imputed values from Quant Studio, Focus-forming assay (FFA) values from CTL Biospot, histological images, and weight loss data.

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Refer to the Methods sections of the open access manuscript.

Institutions

Washington University in St. Louis
Missouri, St Louis

Funders

Novavax (United States)
Gaithersburg

Additional Metadata for Digital Commons Data@Becker

Keywords

Influenza Vaccines, Influenza A Virus, H5N1 Subtype, Vaccination

Intranasal and intramuscular H5-Matrix-M nanoparticle vaccines protects against highly pathogenic Influenza A (H5N1) virus in mice [dataset]

Description

Files

Steps to reproduce

Institutions

Categories

Funders

Additional Metadata for Digital Commons Data@Becker

Licence