The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study

Description

The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a large, prospective, multi-center case-control study focused on identifying genetic and epidemiological risk factors for intracerebral hemorrhage (ICH), with an emphasis on enrolling participants from underrepresented racial and ethnic groups. The study was designed to address known disparities in ICH incidence, location, and outcomes among non-Hispanic white, Black, and Hispanic populations. The published dataset includes DICOM and NIFTI images from 2,942 subjects. Cases were identified through a rapid “hot-pursuit” enrollment strategy at clinical sites, while controls were selected through random digit dialing and matched to cases by age, sex, race/ethnicity, and geographic region. The imaging component of the dataset includes 7,988 CT sessions and 1,472 MR sessions, collected using standardized protocols across participating centers. This dataset provides a valuable resource for studying the radiographic features of ICH and supports analyses of hemorrhage patterns, severity, and outcomes in a racially and ethnically diverse population. This dataset is hosted on the Imaging Cerebrovascular Disease Knowledge Portal (iCDKP), which is supported in part by the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), under Grant No. 1U24NS132940-01. Imaging data has been de-identified and refaced. Users are required to acknowledge both iCDKP and its federal funding source in any presentations or publications that utilize the dataset, following the citation guidelines provided on the dataset’s iCDKP page. To request access, users must register for an account and complete a Data Request License Agreement available via the iCDKP request portal: https://sites.wustl.edu/icdkp/request_data/.

Steps to reproduce

More than 3,000 cases of acute intracerebral hemorrhage (ICH) were enrolled between 2010 and 2015 across 19 participating sites, representing 42 hospitals throughout the United States. Control participants were identified through random digit dialing and matched to cases by age, sex, race/ethnicity, and geographic region. As part of the study design, enrollment was balanced across three racial/ethnic groups, Hispanic, non-Hispanic White, and non-Hispanic Black participants, with a target of 1,000 individuals in each group. A detailed study protocol is available in Stroke: “The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study Protocol” (https://doi.org/10.1161/STROKEAHA.113.002332)

Institutions

• Washington University in St. Louis

  Missouri, St Louis
• University at Buffalo, State University of New York

  New York, Buffalo
• Massachusetts General Hospital

  Massachusetts, Boston
• University of Cincinnati

  Ohio, Cincinnati
• University of Virginia

  Virginia, Charlottesville
• Duke University

  North Carolina, Durham

Categories

Funders

• National Institute of Neurological Disorders and Stroke

  National Institutes of Health

  Bethesda

  Grant ID: U01 NS069763

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